The Chair of Plant Cell Biology at the Faculty of Biology and Biotechnology is looking for a
research associate (m,f,x) for 3 years, 39,83 hours per week, TVL E13
Common denominator to the research in the Üstün Lab is how protein homeostasis (proteostasis), including translation, sorting and degradation of proteins, shapes the response to environmental stimuli. The control of protein homeostasis in response to environmental stimuli has emerged as a strategy to respond to perturbations ranging from ageing to pathological diseases in animals, and plants. There is mounting evidence that translational reprogramming occurs upon various stresses in different systems. To allow rapid, versatile, and cost-efficient responses to sudden environmental changes, eukaryotes utilize reversible translational arrest caused by compartmentalization of transcripts in cytosolic membraneless aggregates formed by phase separation. One such type of aggregates are processing bodies (PBs), dynamic ribonucleoprotein aggregates conserved among eukaryotes. Based on our previous work on PBs (proximity-labelling, transcriptomics) and their involvement in host-bacteria interactions we propose to study how bacteria utilize PBs to repress translation for their own benefit. We aim to use our model system to understand the composition and formation of PBs during stress conditions and how bacteria utilize PBs to manipulate translation during infection.
| extent: | full-time |
| duration: | temporary |
| beginning: | 01.10.2024 |
| application deadline: | 17.06.2024 |
We aim to address following key objectives::
We aim to address following key objectives::
- To investigate the global PB-dependent translatome during infection
- Verify and identify the mRNA composition within PBs during infection
- Investigate the interplay between hormone signaling, TOR activity and PBs
Your profile:
- We are looking for a Postdoc candidate (m,f,x) with experience in molecular biology. Experience with translatome studies and Arabidopsis are highly advantageous. Excellent English communication skills as well as teamwork abilities are expected. A PhD degree in molecular biology, biochemistry or corresponding is required. We offer an innovative, inclusive, and scientifically stimulating environment supported by grants from the DFG and the European Research Council. We use a combination of state-of-the-art techniques (from single-cell RNA sequencing to proximity-labelling) and perform cutting-edge research in plant proteostasis. Work within the project will include microbial, cell biological (confocal microscopy), biochemical (proteomics, in vitro assays), genetic and transcriptomic (Ribo-Seq) approaches using Arabidopsis thaliana as a model organism. More information can be found on our lab homepage: http://theustunlab.com/
Additional information:
At the request of the applicant (m,f,x), the staff council may be involved in selection interviews. https://www.wpr.ruhr-uni-bochum.de/
If the position is funded by third-party funds the employee has no teaching obligation.
German language courses are offered by the University Language Center (ZfA) in the field of German as a Foreign Language (DaF).
https://www.daf.ruhr-uni-bochum.de/sbgk/index.html.en
You can find information about TVL at: https://oeffentlicher-dienst.info/
The Ruhr-Universität Bochum is one of Germany’s leading research universities, addressing the whole range of academic disciplines. A highly dynamic setting enables researchers and students to work across the traditional boundaries of academic subjects and faculties. To create knowledge networks within and beyond the university is RUB’s declared aim.
The Ruhr-Universität Bochum stands for diversity and equal opportunities. For this reason, we favour a working environment composed of heterogeneous teams, and seek to promote the careers of individuals who are underrepresented in our respective professional areas. The Ruhr-Universität Bochum expressly requests job applications from women. In areas in which they are underrepresented they will be given preference in the case of equivalent qualifications with male candidates. Applications from individuals with disabilities are most welcome.
Contact details for your application:
Suayb Üstün, Phone: +49234 32 26467
Travel expenses for interviews cannot be refunded.
For information on the collection of personal data in the application process see: https://www.ruhr-uni-bochum.de/en/information-collection-personal-data-application-process.
We are looking forward to receiving your application with the specification ANR: 3203 until 17.06.2024, send by e-mail to the following address: suayb.uestuen@rub.de
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